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25953-14-4

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25953-14-4 Structure

25953-14-4 Structure
IdentificationBack Directory
[Name]

5'-IODO-5'-DEOXYTHYMIDINE
[CAS]

25953-14-4
[Synonyms]

5'-IODO-5'-DEOXYTHYMIDINE
5'-Deoxy-5'-iodothymidine
5'-Deoxy-5'-iodo-D-thymidine
Thymidine, 5'-deoxy-5'-iodo-
1-[4-HYDROXY-5-(IODOMETHYL)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE
1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
[Molecular Formula]

C10H13IN2O4
[MDL Number]

MFCD04973690
[MOL File]

25953-14-4.mol
[Molecular Weight]

352.13
Chemical PropertiesBack Directory
[Melting point ]

165-168 °C (decomp)
[density ]

1.872±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka]

9.638±0.10(predicted)
Hazard InformationBack Directory
[Uses]

5′-Deoxy-5′-iodothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
[References]

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
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