| Identification | Back Directory | [Name]
3-Pyridinecarboxamide, 2-amino-5-[4-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)- | [CAS]
2616821-92-0 | [Synonyms]
(S)-PERK-IN-5
3-Pyridinecarboxamide, 2-amino-5-[4-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-2-ethylphenyl]-N-(1-methylethyl)- | [Molecular Formula]
C25H26F2N4O3 | [MOL File]
2616821-92-0.mol | [Molecular Weight]
468.5 |
| Hazard Information | Back Directory | [Uses]
(S)-PERK-IN-5 is the S-enantiomer of PERK-IN-5. (S)-PERK-IN-5 (example 39) is a PERK inhibitor, with an IC50 of 0.101-0.250 μM[1][2]. | [References]
[1] Calvo V, et al. Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett. 2021;43:128058. DOI:10.1016/j.bmcl.2021.128058
[2] Alan C. Rigby, et al. Perk inhibitors for treating viral infections. WO2021231782A1. |
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