| Identification | More | [Name]
5-Bromo-2,3-difluoroanisole | [CAS]
261762-35-0 | [Synonyms]
3,4-DIFLUORO-5-METHOXY BROMOBENZENE
5-BROMO-2,3-DIFLUOROANISOLE
5-bromo-2,3-difluoroanisole(5-bromo-2,3-difluorophenol methyl ether)
5-Bromo-2,3-difluoroanisole 97%
BENZENE,5-BROMO-1,2-DIFLUORO-3-METHOXY | [EINECS(EC#)]
670-641-4 | [Molecular Formula]
C7H5BrF2O | [MDL Number]
MFCD01631352 | [Molecular Weight]
223.01 | [MOL File]
261762-35-0.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2909309090 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder | [Synthesis]
In a 3000 L reactor, 201.6 kg of potassium hydroxide (KOH), 253.2 kg of 3,4,5-trifluorobromobenzene and 1500 L of methanol were added sequentially. The reaction kettle was sealed, stirring was turned on and heated to 60°C, and the reaction was maintained for 6 hours until the raw materials were basically reacted completely. The reaction mixture was transferred to a crystallization tank, protected by the passage of nitrogen, cooled to -5 °C with stirring and maintained at this temperature for 5 hours to promote crystallization. Subsequent filtration was performed to afford the target product 2,3-difluoro-5-bromoanisole in 92.0% yield and 99.2% purity. The methanol in the filtrate was recycled and processed for use in subsequent reactions. | [References]
[1] Patent: CN106478377, 2017, A. Location in patent: Paragraph 0037; 0038; 0053; 0054; 0055; 0056; 0061; 0062 |
|
|