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2630378-05-9

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2630378-05-9 Structure

2630378-05-9 Structure
IdentificationBack Directory
[Name]

2-Thiophenecarboxylic acid, 5-[4-(methoxycarbonyl)phenoxy]-4-nitro-, ethyl ester
[CAS]

2630378-05-9
[Synonyms]

USP10 inhibitor Wu-5
2-Thiophenecarboxylic acid, 5-[4-(methoxycarbonyl)phenoxy]-4-nitro-, ethyl ester
[Molecular Formula]

C15H13NO7S
[MOL File]

2630378-05-9.mol
[Molecular Weight]

351.33
Chemical PropertiesBack Directory
[Boiling point ]

491.8±45.0 °C(Predicted)
[density ]

1.385±0.06 g/cm3(Predicted)
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis[1].
[References]

[1] Miao Yu, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612. DOI:10.1038/s41401-020-0455-x
Spectrum DetailBack Directory
[Spectrum Detail]

2-Thiophenecarboxylic acid, 5-[4-(methoxycarbonyl)phenoxy]-4-nitro-, ethyl ester(2630378-05-9)1HNMR
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