| Identification | Back Directory | [Name]
2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)- | [CAS]
2631659-57-7 | [Synonyms]
2H-Pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 6,10b,11,11a-tetrahydro-3-(1H-indol-3-ylmethyl)-6,10b-bis(phenylmethyl)-, (3S,5aS,10bS,11aS)- | [Molecular Formula]
C36H32N4O2 | [MOL File]
2631659-57-7.mol | [Molecular Weight]
552.67 |
| Hazard Information | Back Directory | [Uses]
C3N-Dbn-Trp2 is an inhibitor for ATP-binding cassette transporter ABCB1. C3N-Dbn-Trp2 inhibits the ABCB1-mediated Rhodamine 123 (HY-D0816) efflux in cells HEK293T and HCT-15 with IC50 of 5.9 μM and 2.2 μM. C3N-Dbn-Trp2 inhibits the Doxorubicin (HY-15142A) efflux, enhances the cytotoxicity of Doxorubicin in ABCB1-expressing cells[1]. | [References]
[1] Koh JYP, et al., Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors. Commun Chem. 2024 Jul 13;7(1):158. DOI:10.1038/s42004-024-01225-z |
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