| Chemical Properties | Back Directory | [Boiling point ]
699.1±55.0 °C(predicted) | [density ]
1.456±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
10.01±0.10(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
(R)-Benpyrine is the isomer of Benpyrine (HY-133807), and can be used as an experimental control. Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. | [References]
[1] Weiguang Sun, et al. Discovery of an Orally Active Small Molecule TNF-α Inhibitor. J Med Chem. 2020 Jul 15. DOI:10.1021/acs.jmedchem.0c00377 |
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