| Identification | Back Directory | [Name]
2-Furanmethanamine, 5-(2-chlorophenyl)-N-[[3-(1-pyrrolidinyl)-3-oxetanyl]methyl]- | [CAS]
2640366-38-5 | [Synonyms]
FTO-IN-8
2-Furanmethanamine, 5-(2-chlorophenyl)-N-[[3-(1-pyrrolidinyl)-3-oxetanyl]methyl]- | [Molecular Formula]
C19H23ClN2O2 | [MOL File]
2640366-38-5.mol | [Molecular Weight]
346.85 |
| Chemical Properties | Back Directory | [Boiling point ]
444.4±40.0 °C(Predicted) | [density ]
1.234±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
8.57±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase (FTO) (fat mass- and obesity-associated protein) inhibitor with the IC50 value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity[1]. | [References]
[1] Sarah Huff, et al. Rational Design and Optimization of m6A-RNA Demethylase FTO Inhibitors as Anticancer Agents. J Med Chem. 2022 Aug 8. DOI:10.1021/acs.jmedchem.1c02075 |
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