| Identification | Back Directory | [Name]
Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)- | [CAS]
2649882-80-2 | [Synonyms]
ARN25068
Thieno[3,2-d]pyrimidine-2,4-diamine, N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(phenylmethyl)- | [Molecular Formula]
C19H18N6S | [MOL File]
2649882-80-2.mol | [Molecular Weight]
362.45 |
| Chemical Properties | Back Directory | [Boiling point ]
678.9±65.0 °C(Predicted) | [density ]
1.478±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.22±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation[1]. | [References]
[1] Stefania Demuro, et al. ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders. Eur J Med Chem. 2022 Feb 5;229:114054. DOI:10.1016/j.ejmech.2021.114054 |
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