| Identification | Back Directory | [Name]
Benzenesulfonamide, N-[4'-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)methyl][1,1'-biphenyl]-4-yl]-4-methoxy-N-[(4-methoxyphenyl)sulfonyl]- | [CAS]
2652001-05-1 | [Synonyms]
P-gp inhibitor 4
Benzenesulfonamide, N-[4'-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)methyl][1,1'-biphenyl]-4-yl]-4-methoxy-N-[(4-methoxyphenyl)sulfonyl]- | [Molecular Formula]
C38H38N2O8S2 | [MOL File]
2652001-05-1.mol | [Molecular Weight]
714.85 |
| Hazard Information | Back Directory | [Uses]
P-gp inhibitor 4 (Compound 8b) is a selective P-glycoprotein modulator with an EC50 of 94 nM. P-gp inhibitor 4 increases agent transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells[1]. | [References]
[1] Contino M, et al. One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells. Eur J Med Chem. 2020 Dec 15;208:112843. DOI:10.1016/j.ejmech.2020.112843 |
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