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265312-55-8

265312-55-8 Structure

265312-55-8 Structure
IdentificationBack Directory
[Name]

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
[CAS]

265312-55-8
[Synonyms]

RYUVIDINE
Cdk4 Inhibitor III
2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
[Molecular Formula]

C15H12N2O2S
[MDL Number]

MFCD09971103
[MOL File]

265312-55-8.mol
[Molecular Weight]

284.33
Chemical PropertiesBack Directory
[Boiling point ]

463.8±45.0 °C(Predicted)
[density ]

1.416±0.06 g/cm3(Predicted)
[storage temp. ]

Store at +4°C
[solubility ]

Soluble to 20 mM in DMSO and to 5 mM in ethanol
[form ]

Black-purple solid
[pka]

-1.63±0.20(Predicted)
[color ]

Brown to black
Hazard InformationBack Directory
[Uses]

Ryuvidine is an antifungal agent used against pathogenic fungi.
[Definition]

ChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene.
[General Description]

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
[Biological Activity]

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).
[Biochem/physiol Actions]

Cell permeable: yes
[storage]

Store at +4°C
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