| Identification | Back Directory | [Name]
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE | [CAS]
265312-55-8 | [Synonyms]
RYUVIDINE
Cdk4 Inhibitor III
2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]- | [Molecular Formula]
C15H12N2O2S | [MDL Number]
MFCD09971103 | [MOL File]
265312-55-8.mol | [Molecular Weight]
284.33 |
| Chemical Properties | Back Directory | [Boiling point ]
463.8±45.0 °C(Predicted) | [density ]
1.416±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 20 mM in DMSO and to 5 mM in ethanol | [form ]
Black-purple solid | [pka]
-1.63±0.20(Predicted) | [color ]
Brown to black | [InChI]
InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3 | [InChIKey]
HFPLHASLIOXVGS-UHFFFAOYSA-N | [SMILES]
C12N=C(SC=1C(=O)C=C(NC1C=CC(C)=CC=1)C2=O)C |
| Hazard Information | Back Directory | [Uses]
Ryuvidine is an antifungal agent used against pathogenic fungi. | [Definition]
ChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene. | [General Description]
A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120). | [Biological Activity]
Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively). | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Store at +4°C |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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