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2668297-70-7

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2668297-70-7 Structure

2668297-70-7 Structure

Identification	Back Directory
[Name] 9H-Pyrido[3,4-b]indole-7-carboxylic acid, 1-[(cyclopropylcarbonyl)amino]-, methyl ester
[CAS] 2668297-70-7
[Synonyms] ZDWX-25 9H-Pyrido[3,4-b]indole-7-carboxylic acid, 1-[(cyclopropylcarbonyl)amino]-, methyl ester
[Molecular Formula] C17H15N3O3
[MOL File] 2668297-70-7.mol
[Molecular Weight] 309.32

Chemical Properties	Back Directory
[Boiling point ] 642.4±50.0 °C(Predicted)
[density ] 1.476±0.06 g/cm3(Predicted)
[pka] 13.13±0.20(Predicted)

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[Uses] ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease[1].
[IC 50] GSK-3β: 71 nM (IC₅₀)
[References] [1] Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022;229:114095. DOI:10.1016/j.ejmech.2021.114095

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Company Name:	TargetMol Chemicals Inc.
Telephone:	15002134094
Website:	https://www.targetmol.cn/

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2668297-70-7 491-54-3 252917-06-9 603288-22-8