| Identification | Back Directory | [Name]
2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(1R)-7,8-dichloro-1,2,4,5-tetrahydro-1-methyl-3H-3-benzazepin-3-yl]-3-oxopropyl]-, (5S)- | [CAS]
2688733-96-0 | [Synonyms]
ADAMTS-5-IN-3
2,4-Imidazolidinedione, 5-cyclopropyl-5-[3-[(1R)-7,8-dichloro-1,2,4,5-tetrahydro-1-methyl-3H-3-benzazepin-3-yl]-3-oxopropyl]-, (5S)- | [Molecular Formula]
C20H23Cl2N3O3 | [MOL File]
2688733-96-0.mol | [Molecular Weight]
424.32 |
| Hazard Information | Back Directory | [Description]
ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis[1]. | [Uses]
ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis[1]. | [storage]
Store at -20°C | [References]
[1] Dong Liu, et al. Adamts inhibitors, preparation methods and medicinal uses thereof. WO2021158626A1. |
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