| Identification | Back Directory | [Name]
D-Ala-Lys-AMCA (hydrochloride) | [CAS]
2703746-41-0 | [Synonyms]
D-Ala-Lys-AMCA (hydrochloride)
DAlaLysAMCA hydrochloride,D Ala Lys AMCA hydrochloride | [Molecular Formula]
C21H28N4O6.ClH | [MOL File]
2703746-41-0.mol | [Molecular Weight]
468.93 |
| Hazard Information | Back Directory | [Description]
D-Ala-Lys-AMCA hydrochloride is a proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. | [Uses]
D-Ala-Lys-AMCA hydrochloride is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA hydrochloride may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA hydrochloride can be used for characterizing PEPT1-specific substrates or inhibitors[1][2]. | [References]
[1] Gong Y, et al. Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-anovel strategy for tumor-targeted therapy. Oncol Lett. 2017 Oct;14(4):4158-4166. DOI:10.1152/ajpgi.2001.281.3.G697
[2] Groneberg DA, et al. Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G697-704. DOI:10.1152/ajpgi.2001.281.3.G697 |
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