| Identification | Back Directory | [Name]
1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]- | [CAS]
2708934-53-4 | [Synonyms]
1H-Benzotriazole-1-acetamide, N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]- | [Molecular Formula]
C24H19ClN6O | [MOL File]
2708934-53-4.mol | [Molecular Weight]
442.9 |
| Chemical Properties | Back Directory | [Boiling point ]
752.0±60.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.34±0.10(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Description]
CCF0058981, also known as CCF981, is a ML300-Derived, Noncovalent Inhibitor Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV?2 3CLpro). CCF0058981 demonstrates nanomolar activity in these respective assays, comparable in potency to remdesivir. | [Uses]
CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CLpro (SC2) inhibitor with an IC50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CLpro) with an IC50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research[1]. | [References]
[1] Sang Hoon Han, et al. Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL pro). J Med Chem. 2021 Aug 4;acs.jmedchem.1c00598. DOI:10.1021/acs.jmedchem.1c00598 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|