| Identification | Back Directory | [Name]
Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- | [CAS]
2713577-16-1 | [Synonyms]
Quinazoline, 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1-methyl-1H-pyrazol-5-yl)- | [Molecular Formula]
C25H24N6O | [MOL File]
2713577-16-1.mol | [Molecular Weight]
424.5 |
| Chemical Properties | Back Directory | [Boiling point ]
612.2±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
15.61±0.30(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo. | [Biological Activity]
SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo. | [IC 50]
ATR: 0.013 μM (IC50) | [storage]
Store at -20°C | [References]
[1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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