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2737202-65-0

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2737202-65-0 Structure

2737202-65-0 Structure
IdentificationBack Directory
[Name]

N3-L-Cit-OH (DCHA)
[CAS]

2737202-65-0
[Synonyms]

Hazard InformationBack Directory
[Uses]

N3-L-Cit-OH DCHA is a click chemistry reagent containing an azide group. N3-L-Cit-OH DCHA can be used to construct peptidomimetic ADC linkers using Click-chemistry[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
[References]

[1] Eigenbrot C, et al. Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. J Med Chem. 2018 Feb 8;61(3):989-1000. DOI:10.1021/acs.jmedchem.7b01430
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Company Name: Alfa Chemistry
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