| Identification | Back Directory | [Name]
3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- | [CAS]
2737274-49-4 | [Synonyms]
IDOR-1117-2520
3-Pyridinemethanol, α-(1,3-dimethyl-3-azetidinyl)-5-[5-(1-hydroxy-1-methylethyl)-1,2,4-oxadiazol-3-yl]-α-[4-(1-methylethyl)phenyl]-, (αR)- | [Molecular Formula]
C25H32N4O3 | [MOL File]
2737274-49-4.mol | [Molecular Weight]
436.55 |
| Chemical Properties | Back Directory | [Boiling point ]
573.9±60.0 °C(predicted) | [density ]
1.193±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
12.24±0.29(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
IDOR-1117-2520 is a potent and selective antagonist of CCR6. IDOR-1117-2520 antagonizes the CCL20-mediated calcium flow (IC50 = 63 nM) and inhibits β-arrestin recruitment to human CCR6 (IC50 = 30 nM) in cells expressing recombinant human CCR6. IDOR-1117-2520 can be used for research of autoimmune diseases[1]. | [References]
[1] Meyer EA, et al. Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases. J Med Chem. 2024 May 10. DOI:10.1021/acs.jmedchem.4c00186 |
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