| Identification | Back Directory | [Name]
1H-Imidazole-5-carboxylic acid, 2-(3-cyanophenyl)-1-[(4-cyanophenyl)methoxy]-4-methyl-, ethyl ester | [CAS]
2738381-94-5 | [Synonyms]
ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate
1H-Imidazole-5-carboxylic acid, 2-(3-cyanophenyl)-1-[(4-cyanophenyl)methoxy]-4-methyl-, ethyl ester
ethyl 1[(4cyanobenzyl)oxy]2(3cyanophenyl)4methyl1Himidazole5carboxylate,ethyl 1 [(4 cyanobenzyl)oxy] 2 (3 cyanophenyl) 4 methyl 1H imidazole 5 carboxylate | [Molecular Formula]
C22H18N4O3 | [MOL File]
2738381-94-5.mol | [Molecular Weight]
386.4 |
| Chemical Properties | Back Directory | [Boiling point ]
609.8±65.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
0.20±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
P2Y1/P2Y12 antagonist-1 (compound 24w) is an orally available dual inhibitor of P2Y1 and P2Y12 with antiplatelet activity. P2Y1/P2Y12 antagonist-1 inhibits ADP-induced platelet aggregation in rabbit plasma with an IC50 of 4.23 μM. P2Y1/P2Y12 antagonist-1 exhibits potent inhibitory effects in rat thrombosis model. | [References]
[1] Lei Y, et al. Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y1 and P2Y12 as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor. J Med Chem. 2020 Dec 24;63(24):15752-15772. DOI:10.1021/acs.jmedchem.0c01524 |
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