| Identification | Back Directory | [Name]
4-Thiazoleacetamide, 2-[[6-(hydroxymethyl)-2-pyridinyl]amino]-N-(5-methyl-2-thiazolyl)- | [CAS]
2750644-31-4 | [Synonyms]
HQ005
4-Thiazoleacetamide, 2-[[6-(hydroxymethyl)-2-pyridinyl]amino]-N-(5-methyl-2-thiazolyl)- | [Molecular Formula]
C15H15N5O2S2 | [MOL File]
2750644-31-4.mol | [Molecular Weight]
361.44 |
| Hazard Information | Back Directory | [Uses]
HQ005 is a potent CCNK degrader with an DC50 value of 0.041 μM. HQ005 is a molecular-glue degrader that mediates interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation[1]. | [References]
[1] Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994. DOI:10.7554/eLife.59994 |
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