| Identification | Back Directory | [Name]
JAK-IN-5 hydrochloride | [CAS]
2751323-21-2 | [Synonyms]
JAK-IN-5 hydrochloride
JAK IN 5 hydrochloride,JAKIN5 hydrochloride
JAK-IN-5 hydrochloride(2096999-92-5 Free base) | [Molecular Formula]
C27H32ClFN6O | [MOL File]
2751323-21-2.mol | [Molecular Weight]
511.04 |
| Hazard Information | Back Directory | [Uses]
JAK-IN-5 hydrochloride is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283[1]. | [in vivo]
JAK-IN-5 hydrochloride (compound 1) (oral aspirate, 0.5 mg/mL, 50 μL ) inhibits STAT6 phosphorylation by 60% in IL-13-induced in lung tissue in a mouse model of pSTAT6 induction[2].
JAK-IN-5 hydrochloride (compound 1) (oral aspirate, 0.1-1.0 mg/mL, 50 μL) inhibits 88% of BALF eosinophils in male C57 mice model of Alternaria alternata-induced eosinophilic inflammation of the lung[2].
| [References]
[1] Paul R. Fatheree, et al. JAK Kinase Inhibitor Compounds for Treatment of Respiratory Disease. US20170121327A1.
[2] Venkat R, et al. Methods of treatment using a jak inhibitor compound. US20180311226. |
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