| Chemical Properties | Back Directory | [density ]
1.62±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
10.57±0.50(Predicted) | [color ]
Yellow to green |
| Hazard Information | Back Directory | [Uses]
CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC50= 24 nM). CPS2 can be used for the research of acute myeloid leukemia[1]. | [Biological Activity]
CPS2 is a cell penetrant proteolysis-targeting chimera (PROTAC) th at targets cyclin-dependent kinase 2 (CDK2). CPS2 potently degrades CDK2 in different cell lines. It appears th at it does not induce comparable degradation of other targets | [IC 50]
CDK2: 24 nM (IC50) | [References]
[1] Wang L, et al. Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat Chem Biol. 2021;17(5):567-575 DOI:10.1038/s41589-021-00742-5 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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