| Identification | More | [Name]
N,N'-DIACETYL-1,6-DIAMINOHEXANE | [CAS]
3073-59-4 | [Synonyms]
1,6-DIACETAMIDOHEXANE
HEXAMETHYLENE BISCETAMIDE
N,N'-DIACETYL-1,6-DIAMINOHEXANE
N,N'-DIACETYL-1,6-HEXANEDIAMINE
N,N'-HEXAMETHYLENEBISACETAMIDE
Acetamide, N,N'-1,6-hexanediylbis-
Acetamide, N,N'-hexamethylenebis-
Hexamethylene bisacetamide
hexamethylenebisacetamide
Hexamethylenediacetamide
n,n’-1,6-hexanediylbis-acetamid
n,n’-1,6-hexanediylbisacetamide
n,n’-diacetylhexamethylenediamine
n,n’-hexamethylenebis-acetamid
N,N'-Diacetylhexamethylenediamine
N-[6-(Acetylamino)hexyl]acetamide
NSC-95580
N,N'-Diacetyl-1,6-diaminohexane, 98+%
N,N'-Diacetyl-1,6-hexadiamine
N,Nμ-Diacetyl-1,6-hexanediamine, HMBA | [EINECS(EC#)]
211-363-1 | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD00008684 | [Molecular Weight]
200.28 | [MOL File]
3073-59-4.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder or flakes | [Melting point ]
128-129 °C(lit.)
| [Boiling point ]
338.01°C (rough estimate) | [density ]
0.974 | [refractive index ]
1.4710 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
water: soluble5%, clear, colorless | [form ]
A solid | [pka]
16.20±0.46(Predicted) | [color ]
White to off-white | [Water Solubility ]
water: soluble 5%, clear, colorless | [BRN ]
1775764 | [InChI]
InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14) | [InChIKey]
BNQSTAOJRULKNX-UHFFFAOYSA-N | [SMILES]
C(NC(=O)C)CCCCCNC(=O)C | [CAS DataBase Reference]
3073-59-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R33:Danger of cumulative effects. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
AC2976200
| [HS Code ]
29241990 | [Storage Class]
11 - Combustible Solids | [Toxicity]
human,TDLo,intravenous,4270mg/kg/10D (4270mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBLOOD: THROMBOCYTOPENIA,Cancer Research. Vol. 47, Pg. 5788, 1987. |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder or flakes | [Uses]
N,N′-Hexamethylene bis(acetamide) was used as an inducing agent in obtaining mononuclear cells from the peripheral blood (PB) sample by Ficoll-Hypaque gradient separation. | [Definition]
ChEBI: N-(6-acetamidohexyl)acetamide is a member of acetamides. | [Biological Activity]
Hexamethylene bisacetamide is a tumor cell-differentiating agent. It induces complete differentiation of 754A murine erythroleukemia cells when used at a concentration of 5 mM. Hexamethylene bisacetamide also induces latent HIV-1 viral production in chronically HIV-1-infected U1 cells in a concentration-dependent manner. Implantation of HT-29 colon cancer cells cultured with hexamethylene bisacetamide for seven days, but not 28, reduces tumorigenesis of those cells in mice. Hexamethylene Bisacetamide (HMBA) is a hybrid polar compound originally developed as a differentiation-inducing agent. HMBA can inhibit the activation of several NF kappaB target genes in both lung and breast cancer cell lines. Furthermore, consistent with its ability to inhibit NF kappaB function, HMBA can also sensitize cells to apoptosis. HMBA mediates inhibition of the Akt and ERK/MAPK cascade, both critical for cell survival and proliferation and are well-known regulators of NF kappaB activation[1].
| [in vivo]
Hexamethylene bisacetamide (1000 mg/kg intraperitoneal injection; 500-1000 mg/kg intravenous injection; 400 nmoles 2 μL intracerebroventricular injection; 7 days) has an improved effect in mouse obesity model[5]. | Animal Model: | Mice with diet-induced obese (DIO) model[5] | | Dosage: | 1,000 mg/kg (i.p.);
500 and 1,000 mg/kg (i.v.);
400 nmoles 2 μL (ICV) | | Administration: | Intraperitoneal injection (i.p.); 7 days
Intravenous injection (i.v.); 7 days
Intracerebroventricular injection (ICV); 7 days | | Result: | Ameliorated obese phenotype in DIO mice, reduced weight gain and food intake and improved metabolic parameters in whatever injection way.
Did not cause sickness behaviors in DIO mice in whatever injection way.
Regulate hypothalamic neuropeptide expression in whatever injection way.
|
| [storage]
Store at -20°C | [References]
[1] Anwesha Dey. “Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy.” Cell Cycle 7 23 (2008): 3759–67. |
| Spectrum Detail | Back Directory | [Spectrum Detail]
N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)MS
N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)1HNMR
N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)IR1
N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)IR2
N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)Raman
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J & K SCIENTIFIC LTD.
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Energy Chemical
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Maya High Purity Chemicals
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