| Identification | Back Directory | [Name]
Pyrano[3,4-b]indole, 1-(3,5-difluorophenyl)-1,3,4,9-tetrahydro- | [CAS]
2757804-89-8 | [Synonyms]
PI3K/Akt/mTOR-IN-2
Pyrano[3,4-b]indole, 1-(3,5-difluorophenyl)-1,3,4,9-tetrahydro- | [Molecular Formula]
C17H13F2NO | [MOL File]
2757804-89-8.mol | [Molecular Weight]
285.29 |
| Chemical Properties | Back Directory | [Boiling point ]
427.2±45.0 °C(Predicted) | [density ]
1.343±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (350.52 mM) | [form ]
Solid | [pka]
16.43±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis[1]. | [storage]
Store at -20°C | [References]
[1] Qin J, Sun X, Ma Y, et al. Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway [published online ahead of print, 2021 Dec DOI:10.1016/j.bmc.2021.116594 |
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