| Identification | Back Directory | [Name]
N-(3,4-Dimethylphenyl)-2,3,3a,4,5,9b-hexahydro-4-[4-(2-methyl-1-oxopropyl)phenyl]furo[3,2-c]quinoline-8-sulfonamide | [CAS]
2761969-85-9 | [Synonyms]
MDM2/XIAP-IN-2
N-(3,4-Dimethylphenyl)-2,3,3a,4,5,9b-hexahydro-4-[4-(2-methyl-1-oxopropyl)phenyl]furo[3,2-c]quinoline-8-sulfonamide | [Molecular Formula]
C29H32N2O4S | [MOL File]
2761969-85-9.mol | [Molecular Weight]
504.64 |
| Chemical Properties | Back Directory | [Boiling point ]
679.0±65.0 °C(Predicted) | [density ]
1.235±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
9.51±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC50 value of 0.3 μM[1]. | [References]
[1] Wu Z, et al. Discovery of N-(3, 4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2, 3, 3a, 4, 5, 9b-hexahydrofuro [3, 2-c] quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor[J]. Journal of medicinal chemistry, 2021, 64(4): 1930-1950. |
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