| Identification | Back Directory | [Name]
3-Pyridinecarboxamide, 4-[(2,6-dichlorophenyl)thio]-N-[3-[(dimethylamino)carbonyl]phenyl]-1,2-dihydro-2-oxo-6-(trifluoromethyl)- | [CAS]
2763260-38-2 | [Synonyms]
3-Pyridinecarboxamide, 4-[(2,6-dichlorophenyl)thio]-N-[3-[(dimethylamino)carbonyl]phenyl]-1,2-dihydro-2-oxo-6-(trifluoromethyl)- | [Molecular Formula]
C22H16Cl2F3N3O3S | [MOL File]
2763260-38-2.mol | [Molecular Weight]
530.35 |
| Chemical Properties | Back Directory | [Boiling point ]
642.8±55.0 °C(Predicted) | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
5.12±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM[1]. | [Uses]
NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM[1]. | [References]
[1] Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402. DOI:10.1038/s41467-019-09358-9 |
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