| Chemical Properties | Back Directory | [Boiling point ]
691.6±55.0 °C(Predicted) | [density ]
1.276±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
5.54±0.38(Predicted) | [color ]
Light brown to gray |
| Hazard Information | Back Directory | [Uses]
TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology[1]. | [References]
[1] Kharbanda A, et al. Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology [published online ahead of print, 2021 Aug 12]. Eur J Med Chem. 2021;225:113763. DOI:10.1016/j.ejmech.2021.113763 |
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