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2764772-88-3

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2764772-88-3 Structure

2764772-88-3 Structure
IdentificationBack Directory
[Name]

4-Piperidinamine, N-[3-[[6,7-dimethoxy-2-[4-(trifluoromethyl)phenyl]-4-quinolinyl]oxy]propyl]-1-methyl-
[CAS]

2764772-88-3
[Synonyms]

EGFR-IN-46
4-Piperidinamine, N-[3-[[6,7-dimethoxy-2-[4-(trifluoromethyl)phenyl]-4-quinolinyl]oxy]propyl]-1-methyl-
[Molecular Formula]

C27H32F3N3O3
[MOL File]

2764772-88-3.mol
[Molecular Weight]

503.56
Chemical PropertiesBack Directory
[Boiling point ]

574.3±50.0 °C(Predicted)
[density ]

1.26±0.1 g/cm3(Predicted)
[pka]

9.51±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1].
[IC 50]

EGFR: 20.17 nM (IC50); FAK: 14.25 nM (IC50)
[References]

[1] Elbadawi MM, et al. 2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights. J Enzyme Inhib Med Chem. 2022 Dec;37(1):349-372. DOI:10.1080/14756366.2021.2015344
2764772-88-3 suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Telephone: 13816613772
Website: https://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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2764772-88-3 154-17-6