| Identification | Back Directory | [Name]
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- | [CAS]
2765218-56-0 | [Synonyms]
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- | [Molecular Formula]
C16H15N3O2S | [MOL File]
2765218-56-0.mol | [Molecular Weight]
313.37 |
| Chemical Properties | Back Directory | [Boiling point ]
559.1±45.0 °C(Predicted) | [density ]
1.266±0.06 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
13.06±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
PY-60 is a novel activator of YAP, promoting expansion of epidermal keratinocytes ex vivo and in vivo, targeting ANXA2 to activate YAP, activating a robust, YAP- dependent transcriptional program in multiple cell types. Chemical proteomics revealed the relevant target of PY-60 to be annexin A2 (ANXA2), a protein that directly associates with YAP at the cell membrane in response to increased cell density. PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP. | [Uses]
PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 μM. PY-60 directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity[1]. | [in vivo]
PY-60 (10 uM; applied topically to the dorsal skin of wild-type adult C57BL/6 mice over the course of 10 days) promotes a dramatic expansion of keratinocytes and K14-positive precursors, as assessed by hematoxylin and eosin and anti-K14 histological staining at the study end. PY-60 results in an approximate doubling of epidermal thickness, a result derived from an increased number of keratinocytes per unit length of skin[1]. | [References]
[1] Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021;17(7):767-775. DOI:10.1038/s41589-021-00755-0 |
|
| Company Name: |
Shanghai Bank Pharma Limited
|
| Tel: |
021-2221346380 021-54220652 17701603001 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList20106/0_EN.htm |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|