| Identification | Back Directory | [Name]
Phenol, 5-chloro-2-[4-[(2-hydroxy-2-methylpropyl)amino]pyrido[3,4-d]pyridazin-1-yl]- | [CAS]
2769040-91-5 | [Synonyms]
NLRP3-IN-11
Phenol, 5-chloro-2-[4-[(2-hydroxy-2-methylpropyl)amino]pyrido[3,4-d]pyridazin-1-yl]- | [Molecular Formula]
C17H17ClN4O2 | [MOL File]
2769040-91-5.mol | [Molecular Weight]
344.8 |
| Chemical Properties | Back Directory | [Boiling point ]
613.2±50.0 °C(Predicted) | [density ]
1.404±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.18±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases including NASH, atherosclerosis and other cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout, and numerous other autoinflammatory diseases[1]. | [IC 50]
NLRP3: <0.3 μM (IC50) | [References]
[1] HY-W048205, et al. Compounds for inhibiting NLRP3 and uses thereof. Patent. US11319319B1. |
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