| Chemical Properties | Back Directory | [Boiling point ]
366.8±42.0 °C(Predicted) | [density ]
1.370±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
3.17±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis[1]. | [References]
[1] Wu H, et, al. Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells. Eur J Med Chem. 2023 Aug 5;256:115470. DOI:10.1016/j.ejmech.2023.115470 |
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