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2778330-90-6

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2778330-90-6 Structure

2778330-90-6 Structure

Identification	Back Directory
[Name] JAK1-IN-13
[CAS] 2778330-90-6
[Synonyms] JAK1-IN-13
[Molecular Formula] C23H26F3N5O
[MOL File] 2778330-90-6.mol
[Molecular Weight] 445.48

Chemical Properties	Back Directory
[density ] 1.309±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ] Solid
[pka] 13.97±0.40(predicted)
[color ] White to off-white

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[Uses] JAK1-IN-13 (compound 36b) is an orally active, potent and highly selective inhibitor of JAK1 with an IC50 of 0.044 nM. JAK1-IN-13 significantly decreases STAT3 phosphorylation[1].
[References] [1] Park E, et al. Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis. J Med Chem. 2023 Dec 14;66(23):16342-16363. DOI:10.1021/acs.jmedchem.3c01712

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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