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2796282-58-9

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2796282-58-9 Structure

2796282-58-9 Structure
IdentificationBack Directory
[Name]

4-[(Hydroxyamino)carbonyl]-N-2-naphthalenylbenzeneacetamide
[CAS]

2796282-58-9
[Synonyms]

4-[(Hydroxyamino)carbonyl]-N-2-naphthalenylbenzeneacetamide
[Molecular Formula]

C19H16N2O3
[MOL File]

2796282-58-9.mol
[Molecular Weight]

320.34
Chemical PropertiesBack Directory
[density ]

1.342±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[pka]

8.88±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

HDAC6-IN-9 (compound 12c) is a potent and selective HDAC6 inhibitor with IC50 values of 11.8, 15.2, 4.2, 139.6, 21.3 nM for HDAC1,HDAC3, HDAC6, HDAC8, HDAC10, respectively. HDAC6-IN-9 shows anti-proliferative activities[1].
[IC 50]

HDAC1: 11.8 nM (IC50); HDAC3: 15.2 nM (IC50); HDAC6: 4.2 nM (IC50); HDAC8: 139.6 nM (IC50); HDAC10: 21.3 nM (IC50)
[References]

[1] Li X,et al. Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy. Bioorg Chem. 2022 Aug;125:105874. DOI:10.1016/j.bioorg.2022.105874
Spectrum DetailBack Directory
[Spectrum Detail]

4-[(Hydroxyamino)carbonyl]-N-2-naphthalenylbenzeneacetamide(2796282-58-9)1HNMR
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2796282-58-9 2158718-92-2 847249-57-4 1440210-02-5 73190-70-2 935881-37-1