| Identification | Back Directory | [Name]
1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- | [CAS]
2815263-05-7 | [Synonyms]
1H-Indole, 3-[[6-[4-(4-morpholinylmethyl)phenyl]-5-phenyl-1,2,4-triazin-3-yl]methyl]- | [Molecular Formula]
C29H27N5O | [MOL File]
2815263-05-7.mol | [Molecular Weight]
461.56 |
| Chemical Properties | Back Directory | [Boiling point ]
693.6±65.0 °C(Predicted) | [density ]
1.251±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
16.13±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GPR84 antagonist 3 (compound 42) is a potent GPR84 (G-protein-coupled receptor 84) antagonist. GPR84 antagonist 3 inhibits GTPγS, with a pIC50 of 8.28. GPR84 antagonist 3 has a favorable pharmacokinetic profile suitable[1]. | [in vivo]
GPR84 antagonist 3 (compound 42) (1 mg/kg (IV), 10 mg/kg (Orally); once) has a good elimination half-life (2.51 h), moderate rate of clearance, and bioavailability[1]. | Animal Model: | Male C57BL/6J mice (n = 3)[1] | | Dosage: | 1 mg/kg (IV), 10 mg/kg (Orally) | | Administration: | IV, Orally; once (Pharmacokinetic Analysis) | | Result: | Pharmacokinetic Parameters of GPR84 antagonist 3 in Male C57BL/6J mice[1].
| IV (1 mg/kg) | PO (10 mg/kg) | | half-life (h) | 2.51 ± 6.55 | | | CL (mL/min/kg) | 38.9 ± 13.9 | | | Vss (L/kg) | 7.24 ± 9.2 | | | C0 (ng/mL) | 394 ± 19.1 | | | AUCall (ng/mL·h) | 420 ± 12.5 | 1590 ± 18.7 | | Tmax (h) | | 1 | | Cmax (ng/mL) | | 402 ± 31.8 | | F (%) | | 36.8 ± 18.7 |
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| [References]
[1] Mahindra A, et al. Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists. J Med Chem. 2022 Aug 10. DOI:10.1021/acs.jmedchem.2c00804 |
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