ChemicalBook--->CAS DataBase List--->2834106-06-6

2834106-06-6

Request For Quotation
2834106-06-6 Structure

2834106-06-6 Structure
IdentificationBack Directory
[Name]

NA
[CAS]

2834106-06-6
[Synonyms]

[Molecular Formula]

C21H17F4N3O3S
[MOL File]

2834106-06-6.mol
[Molecular Weight]

467.44
Chemical PropertiesBack Directory
[density ]

1.40±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

LTGO-33 is a potent and selective voltage-gated sodium channel NaV1.8 inhibitor. LTGO-33 inhibits NaV1.8 in the nM potency range and exhibits over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. LTGO-33 exhibits state-independent inhibition with similar potencies on channels in the closed and inactivated conformations. LTGO-33 inhibits native TTX-R NaV1.8 currents in non-human primate and human DRG neurons, where it reduces action potential firing. LTGO-33 can be used for pain disorders research[1].
[IC 50]

hNav1.8
[References]

[1] Gilchrist JM, et al. Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action. Mol Pharmacol. 2024 Feb 15;105(3):233-249. DOI:10.1124/molpharm.123.000789
Spectrum DetailBack Directory
[Spectrum Detail]

LTGO-33(2834106-06-6)1HNMR
2834106-06-6 suppliers list
Company Name: WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.  
Telephone: 17702719238
Website: http://www.sun-shinechem.com/
Company Name: Chuzhou KeMail Chemical Technology Co., Ltd  
Telephone: 0550-5196001 15000891977
Website: https://www.chemicalbook.com/ShowSupplierProductsList19947/0_EN.htm
Company Name: DC Chemicals  
Telephone: 021-58447131 13564518121
Website: https://www.chemicalbook.com/ShowSupplierProductsList927327/0_EN.htm
Company Name: Chunchuang (Wuhan) Technology Co., Ltd  
Telephone: 15727060112
Website: www.chemicalbook.com/showsupplierproductslist1427518/0_en.htm
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: Chengdu PEIP Pharmaceutical Technology Co., LTD.  
Telephone: 028-61715638 18011352545
Website: www.chemicalbook.com/ShowSupplierProductsList554034/0_EN.htm
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Telephone: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
Company Name: Shaanxi Dideu New Materials Co. Ltd  
Telephone: 18192503167
Website:
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd  
Telephone: +86-0533-2185556 +86-15965530500
Website: https://www.chemicalbook.com/manufacturer/hangyu-chemical-25178/
Tags:2834106-06-6 Related Product Information
2834106-06-6 55837-20-2 396-01-0 298-46-4 125-33-7 5369-03-9