| Identification | More | [Name]
6-Amino-m-cresol | [CAS]
2835-98-5 | [Synonyms]
3-HYDROXY-4-METHYLANILINE
4-AMINO-2-HYDROXYTOLUENE
5-AMINO-2-METHYLPHENOL
5-AMINO-O-CRESOL
JAROCOL 2M5AP
6-amino-meta-cresol
6-Amino-m-cresol
2-Amino-5-methylphenol
2-AMINO-5-METHYLPHENOL 98%
6-Amino-m-methylphenol
m-Hydroxy-p-toluidine
Phenol, 2-amino-5-methyl-
6-AMINO-M-CRESOL, 4-AMINO-3-HYDROXYTOLUENE, 2-AMINO-5-METHYLPHENOL, 2-HYDROXY-4-METHYLANILINE
2-Amino-5-methylphenol
2-Hydroxy-4-methylaniline
3-Methyl-6-aminophenol
4-Amino-3-hydroxytoluene
6-Amino-m-cresol
2-Hydroxy-4-methylaniline, 4-Amino-3-hydroxytoluene, 6-Amino-m-cresol
6-Amino-meta-cresol 98% | [EINECS(EC#)]
220-618-6 | [Molecular Formula]
C7H9NO | [MDL Number]
MFCD00043922 | [Molecular Weight]
123.15 | [MOL File]
2835-98-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Beige to brown crystal powder | [Melting point ]
160-162 °C(lit.)
| [Boiling point ]
229.26°C (rough estimate) | [density ]
1.0877 (rough estimate) | [refractive index ]
1.5380 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.87±0.10(Predicted) | [color ]
Beige to Dark Beige | [Water Solubility ]
soluble | [Detection Methods]
HPLC | [BRN ]
386144 | [Stability:]
Hygroscopic | [Cosmetics Ingredients Functions]
HAIR DYEING | [InChI]
1S/C7H9NO/c1-5-2-3-6(8)7(9)4-5/h2-4,9H,8H2,1H3 | [InChIKey]
HCPJEHJGFKWRFM-UHFFFAOYSA-N | [SMILES]
Cc1ccc(N)c(O)c1 | [LogP]
0.900 (est) | [CAS DataBase Reference]
2835-98-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Phenol, 2-amino-5-methyl-(2835-98-5) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
1
| [RTECS ]
SJ6090000
| [Hazard Note ]
Irritant | [HS Code ]
29225090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Skin Sens. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
Beige to brown crystal powder | [Uses]
2-Amino-5-methylphenol was used in the synthesis of tridentate Schiff base ligand and novel non-metallocene catalysts with phenoxy-imine ligands. | [General Description]
2-Amino-5-methylphenol reacts with bovine hemoglobin to form 2-amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one, which inhibits the proliferation of Poliovirus in Vero cells. It is converted to dihydrophenoxazinone by purified human hemoglobin. | [Synthesis]
The general procedure for the synthesis of 6-aminoresorcinol from 6-nitroresorcinol was as follows: 5-methyl-2-nitrophenol (1.0 g, 6.53 mmol) was dissolved in methanol (10 mL) at 23 °C, and Pd/C catalyst (10 wt%, 400 mg) was added. The reaction mixture was deoxygenated at low temperature, followed by replacement of air in the system with hydrogen (supplied via a balloon). After the reaction was stirred for 5 h under hydrogen atmosphere, the reaction mixture was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed with methanol (100 mL). Finally, the combined filtrates were concentrated under reduced pressure to afford 2-amino-5-methylphenol (801 mg, 100% yield). | [Purification Methods]
Crystallise it from H2O, 50% EtOH, or toluene. [Beilstein | [References]
[1] Patent: US2006/211603, 2006, A1. Location in patent: Page/Page column 69
[2] Advanced Synthesis and Catalysis, 2013, vol. 355, # 5, p. 907 - 911
[3] Journal of Heterocyclic Chemistry, 1982, vol. 19, # 6, p. 1545 - 1547
[4] Synthesis, 2001, # 1, p. 81 - 84
[5] Justus Liebigs Annalen der Chemie, 1902, vol. 322, p. 18 |
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