| Identification | Back Directory | [Name]
IDO1-IN-25 | [CAS]
2841467-86-3 | [Synonyms]
IDO1-IN-25
Benzoxazole, 5,6-dichloro-2-[[(4-chlorophenyl)methyl]sulfinyl]- | [Molecular Formula]
C14H8Cl3NO2S | [MOL File]
2841467-86-3.mol | [Molecular Weight]
360.64 |
| Hazard Information | Back Directory | [Uses]
IDO1-IN-25 is a dual inhibitor of IDO1/TDO2, with IC50 values of 0.17 μM and 3.2 μM, respectively. IDO1-IN-25 can effectively inhibit the production of NO in RAW264.7 cells stimulated by lipopolysaccharide (LPS). IDO1-IN-25 can exert anti-inflammatory effects in a mouse ear edema acute inflammation model induced by croton oil[1]. | [References]
[1] Wang T, et al. Rational design of 2-benzylsulfinyl-benzoxazoles as potent and selective indoleamine 2,3-dioxygenase 1 inhibitors to combat inflammation. Bioorg Chem. 2024 Nov;152:107740. DOI:10.1016/j.bioorg.2024.107740 |
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