2841467-86-3

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2841467-86-3 Structure

Identification	Back Directory
[Name] IDO1-IN-25
[CAS] 2841467-86-3
[Synonyms] IDO1-IN-25 Benzoxazole, 5,6-dichloro-2-[[(4-chlorophenyl)methyl]sulfinyl]-
[Molecular Formula] C14H8Cl3NO2S
[MOL File] 2841467-86-3.mol
[Molecular Weight] 360.64

Chemical Properties	Back Directory
[Boiling point ] 540.8±60.0 °C(predicted)
[density ] 1.64±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] -3.31±0.30(predicted)

Hazard Information	Back Directory
[Uses] IDO1-IN-25 is a dual inhibitor of IDO1/TDO2, with IC50 values of 0.17 μM and 3.2 μM, respectively. IDO1-IN-25 can effectively inhibit the production of NO in RAW264.7 cells stimulated by lipopolysaccharide (LPS). IDO1-IN-25 can exert anti-inflammatory effects in a mouse ear edema acute inflammation model induced by croton oil[1].
[References] [1] Wang T, et al. Rational design of 2-benzylsulfinyl-benzoxazoles as potent and selective indoleamine 2,3-dioxygenase 1 inhibitors to combat inflammation. Bioorg Chem. 2024 Nov;152:107740. DOI:10.1016/j.bioorg.2024.107740

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