| Identification | More | [Name]
2-Amino-5-chlorophenol | [CAS]
28443-50-7 | [Synonyms]
2-AMINO-5-CHLOROPHENOL
4-CHLORO-2-HYDROXYANILINE
TIMTEC-BB SBB004137 | [EINECS(EC#)]
249-020-3 | [Molecular Formula]
C6H6ClNO | [MDL Number]
MFCD02093863 | [Molecular Weight]
143.57 | [MOL File]
28443-50-7.mol |
| Chemical Properties | Back Directory | [Appearance]
light brown fine crystalline powder | [Melting point ]
145-153 °C (lit.) | [Boiling point ]
185.5°C (rough estimate) | [density ]
1.2028 (rough estimate) | [vapor pressure ]
0.002-0.094Pa at 20-50℃ | [refractive index ]
1.5618 (estimate) | [storage temp. ]
-20°C, stored under nitrogen | [solubility ]
soluble in Methanol | [form ]
Powder | [pka]
8.79±0.10(Predicted) | [color ]
Light brown | [Detection Methods]
HPLC | [InChI]
InChI=1S/C6H6ClNO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2 | [InChIKey]
FZCQMIRJCGWWCL-UHFFFAOYSA-N | [SMILES]
C1(O)=CC(Cl)=CC=C1N | [CAS DataBase Reference]
28443-50-7(CAS DataBase Reference) | [EPA Substance Registry System]
28443-50-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
6.1 | [HS Code ]
29222990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
light brown fine crystalline powder | [Uses]
2-Amino-5-chlorophenol may be used to synthesize 2-amino-5-chloromuconic semialdehyde and benzoxazole derivatives. | [Definition]
ChEBI: Phenol carrying amino and chloro substituents at positions 2 and 5 respectively. It is part of the degradation pathway of 4-chloronitrobenzene, CHEBI:34399. | [General Description]
2-Amino-5-chlorophenol can be synthesized from 2-chloro-5-nitrophenol via reduction. It can also be obtained from 1-chloro-4-nitrobenzene by using a bacterial strain LW1. 2-Amino-5-chlorophenol participates in the condensation reaction with acetylferrocene to afford ferrocenyl Schiff bases bearing a phenol group. |
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