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2848720-31-8

2848720-31-8 Structure

2848720-31-8 Structure
IdentificationBack Directory
[Name]

3-Quinolinecarboxamide, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-N-[4-[[[2-(1-piperidinyl)ethyl]amino]carbonyl]phenyl]-
[CAS]

2848720-31-8
[Synonyms]

3-Quinolinecarboxamide, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-N-[4-[[[2-(1-piperidinyl)ethyl]amino]carbonyl]phenyl]-
[Molecular Formula]

C30H37FN6O3
[MOL File]

2848720-31-8.mol
[Molecular Weight]

548.65
Chemical PropertiesBack Directory
[Boiling point ]

818.4±65.0 °C(Predicted)
[density ]

1.263±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

11.17±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

microRNA-21-IN-1 (compound A7) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC50s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer[1].
[References]

[1] Xi XX, et al. Identification of benzamides derivatives of norfloxacin as promising microRNA-21 inhibitors via repressing its transcription. Bioorg Med Chem. 2022;66:116803. DOI:10.1016/j.bmc.2022.116803
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