| Identification | Back Directory | [Name]
3-Quinolinecarboxamide, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-N-[4-[[[2-(1-piperidinyl)ethyl]amino]carbonyl]phenyl]- | [CAS]
2848720-31-8 | [Synonyms]
3-Quinolinecarboxamide, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-N-[4-[[[2-(1-piperidinyl)ethyl]amino]carbonyl]phenyl]- | [Molecular Formula]
C30H37FN6O3 | [MOL File]
2848720-31-8.mol | [Molecular Weight]
548.65 |
| Chemical Properties | Back Directory | [Boiling point ]
818.4±65.0 °C(Predicted) | [density ]
1.263±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.17±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
microRNA-21-IN-1 (compound A7) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC50s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer[1]. | [References]
[1] Xi XX, et al. Identification of benzamides derivatives of norfloxacin as promising microRNA-21 inhibitors via repressing its transcription. Bioorg Med Chem. 2022;66:116803. DOI:10.1016/j.bmc.2022.116803 |
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