| Chemical Properties | Back Directory | [Boiling point ]
561.4±60.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-0.44±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
EIF2α activator 1 (Compound 40) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 1 increases the expression level of eIF2α downstream proteins, ATF and CHOP. EIF2α activator 1 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.00 and 19.3 μM, respectively[1]. | [IC 50]
eIF2 | [References]
[1] Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501. DOI:10.1016/j.ejmech.2022.114501 |
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