| Identification | Back Directory | [Name]
3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)- | [CAS]
2857049-72-8 | [Synonyms]
3-Morpholinemethanol, 4-[2-[2-[[3-(2-amino-6-chloro-4-pyrimidinyl)-1-(difluoromethyl)-1H-pyrazol-4-yl]methyl]phenoxy]ethyl]-, (3R)- | [Molecular Formula]
C22H25ClF2N6O3 | [MOL File]
2857049-72-8.mol | [Molecular Weight]
494.92 |
| Chemical Properties | Back Directory | [Boiling point ]
701.0±70.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Soluble | [form ]
Solid | [pka]
14.85±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TDI-11861 is second-generation soluble Adenylyl Cyclase (sAC, ADCY10)?inhibitor?with slow dissociation rates. TDI-11861 inhibits sAC cellular with an IC50 value of 5.5 nM[1]. | [References]
[1] Miller M, et al. Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J Med Chem. 2022 Nov 8. DOI:10.1021/acs.jmedchem.2c01133 |
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