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301177-43-5

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301177-43-5 Structure

301177-43-5 Structure
IdentificationBack Directory
[Name]

ESI-08
[CAS]

301177-43-5
[Synonyms]

ESI-08
EPAC2,cAMP,ESI08,ESI 08,exchange,proteins,EPAC,Ras,inhibit,EPAC1,ESI-08,Inhibitor
5-Pyrimidinecarbonitrile, 4-cyclohexyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-
[Molecular Formula]

C20H23N3OS
[MDL Number]

MFCD01313047
[MOL File]

301177-43-5.mol
[Molecular Weight]

353.48
Chemical PropertiesBack Directory
[storage temp. ]

4°C, protect from light
[solubility ]

DMSO : 100 mg/mL (282.90 mM; ultrasonic and warming and heat to 60°C)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1].
[storage]

4°C, protect from light
Spectrum DetailBack Directory
[Spectrum Detail]

ESI-08(301177-43-5)1HNMR
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