| Hazard Information | Back Directory | [Uses]
JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma[1]. | [in vivo]
JQKD82 (50-75 mg/kg; i.p.; twice a day for 3 weeks) trihydrochloride has anti-multiple myeloma activity[1].
JQKD82 trihydrochloride displays an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo[1]. | Animal Model: | Six-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice (bearing MOLP-8 TurboGFP-Luc cells)[1] | | Dosage: | 50 mg/kg, 75 mg/kg | | Administration: | i.p.; twice a day for 3 weeks | | Result: | Significantly reduced tumor burden.
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KDM5 | [References]
[1] Jun Qi, et al. Histone demethylase 5 inhibitors and uses thereof. WO2020033377A1. |
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