| Identification | More | [Name]
Cholesteryl sodium sulfate | [CAS]
2864-50-8 | [Synonyms]
3BETA-HYDROXY-5-CHOLESTENE 3-SULFATE SODIUM SALT
3-BETA-HYDROXY-5-CHOLESTENE 3-SULPHATE
5-CHOLESTEN-3BETA-OL 3-SULFATE SODIUM
5-CHOLESTEN-3BETA-OL SULFATE SODIUM SALT
5-CHOLESTEN-3-BETA-OL SULPHATE
5-CHOLESTEN-3-BETA-OL SULPHATE, SODIUM SALT
CHOLESTEROL 3-SULFATE SODIUM SALT
CHOLESTEROL, HYDROGEN SULFATE
CHOLESTERYL SODIUM SULFATE
CHOLESTERYL SODIUM SULFATE SODIUM SALT
CHOLESTERYL SODIUM SULPHATE
CHOLESTERYL SULFATE SODIUM
CHOLESTERYL SULFATE SODIUM SALT
SCS
SODIUM CHOLESTERYL SULFATE
CHOLESTEROL 3 SULFATE SODIUM
5-cholesten-3β-ol sulfate sodium salt
CHOLESTEROL SULFATE SODIUM (SCS)
SODIUM CHOLESTEROL SULFATE
(3)-Cholest-5-en-3-ol 3-(Hydrogen Sulfate) Sodium Salt | [Molecular Formula]
C27H45NaO4S | [MDL Number]
MFCD00079091 | [Molecular Weight]
488.7 | [MOL File]
2864-50-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Solid | [Melting point ]
178-180°C | [storage temp. ]
2-8°C
| [solubility ]
Methanol (Slightly, Heated) | [form ]
White to off-white powder. | [color ]
White to Off-White | [biological source]
synthetic | [Usage]
Principal sterol of the higher animals. Found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Main constituent of gallstones. | [BRN ]
3899884 | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [InChIKey]
ZKMOLHRAYRDKHW-SMRZMENRNA-N | [SMILES]
C[C@]12CC[C@H](OS(O)(=O)=O)CC1=CC[C@@]1([H])[C@]3([H])CC[C@]([H])([C@H](C)CCCC(C)C)[C@@]3(C)CC[C@]21[H].[NaH] |&1:1,4,14,16,20,22,30,34,r| | [CAS DataBase Reference]
2864-50-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Cholesterol sulfate is an endogenous component of cell membranes where it serves as a substrate for steroid synthesis, influences lipid metabolism, stabilizes cell membranes, regulates the activity of functional proteins, and plays a role in keratinocyte differentiation and development of the epidermal barrier.1 This synthetic formulation can be used to form nonconventional liposomes in order to study cellular membrane properties.2 | [Chemical Properties]
White to Off-White Solid | [Uses]
Principal sterol of the higher animals. Found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Main constituent of gallstones. | [in vivo]
Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 6 days) antagonizes acute ulcerative colitis induced by DSS (HY-116282C) in male C57BL/6J mice, prevents weight loss, colon shortening and tissue damage, and reverses the exacerbated symptoms in Sult2b1△IEC mice[2].
Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 33 days) improves survival and reduces inflammation in male C57BL/6J mice with chronic colitis induced by DSS[2].
Cholesteryl sulfate sodium (0.004% diet; oral; once daily, 42 days) alleviates spontaneous colitis caused by IL-10 deficiency in female IL-10-/- mice and reduces body weight loss and tissue damage[2].
Cholesteryl sulfate sodium (SCS) can synergize with Mitoxantrone hydrochloride (HY-13502A) to exert antitumor activity through a nano-delivery system[3].
| [References]
[1] CHARLES A STROTT Yuko H. Cholesterol sulfate in human physiology: what’s it all about?[J]. Journal of Lipid Research, 2003, 44 7: 1268-1278. DOI: 10.1194/jlr.r300005-jlr200 |
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