| Identification | Back Directory | [Name]
Dicycloplatin (DCP) | [CAS]
287402-09-9 | [Synonyms]
Dicydoplatin
Dicycloplatin
Dicycloplatin (DCP) | [Molecular Formula]
C12H18N2O8Pt | [MDL Number]
MFCD30478517 | [MOL File]
287402-09-9.mol | [Molecular Weight]
513.37 |
| Hazard Information | Back Directory | [Uses]
Dicycloplatin is a DNA damage inducer. Dicycloplatin induces DNA damage by activating biphosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1) and triphosphorylated p53. Dicycloplatin can induce cell cycle arrest, inhibit proliferation and lead to apoptosis in prostate cancer PC3 cells and lung cancer NCI/H446 cells. Dicycloplatin can be used in cancer researchr[1]. | [References]
[1] Yu J J, et al. Dicycloplatin, a novel platinum analog in chemotherapy: synthesis of chinese pre-clinical and clinical profile and emerging mechanistic studies[J]. Anticancer Research, 2014, 34(1): 455-463. PMID:24403501 |
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