| Chemical Properties | Back Directory | [Boiling point ]
621.372±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.383±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.663±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis[1]. | [IC 50]
CA Ⅸ: 0.33 μM (IC50); CA XII: 0.68 μM (IC50); NPP1: 1.13 μM (IC50); NPP2: 1.07 μM (IC50); NPP3: 0.74 μM (IC50) | [References]
[1] Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022. |
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