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2883498-73-3

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2883498-73-3 Structure

2883498-73-3 Structure
IdentificationBack Directory
[Name]

ZL-Pin13
[CAS]

2883498-73-3
[Synonyms]

ZL-Pin13
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[Uses]

ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC50 of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the Pin1 substrates in MDA-MB-231 cells[1].
[References]

[1] Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J Med Chem. 2022;65(3):2174-2190. DOI:10.1021/acs.jmedchem.1c01686
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