| Chemical Properties | Back Directory | [Boiling point ]
575.7±45.0 °C(Predicted) | [density ]
1.373±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
6.19±0.49(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
RIPK2-IN-5 (compound 14) is a high affinity and excellent selectivity RIPK2 inhibitor with an IC50 value of 5.1nM. RIPK2-IN-5 has cellular anti-inflammatory effect and can reduce the secretion of MDP-induced TNF-α with a dose-dependent manner. RIPK2-IN-5 shows moderate stability in human liver microsome. RIPK2-IN-5 can be used for the research of immune diseases[1]. | [References]
[1] Fan T, et al. Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):282-293. DOI:10.1080/14756366.2022.2148317 |
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