| Identification | Back Directory | [Name]
2,4(1H,3H)-Pyrimidinedione, 1-[[5-(2,4-difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl- | [CAS]
2894848-07-6 | [Synonyms]
2,4(1H,3H)-Pyrimidinedione, 1-[[5-(2,4-difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl- | [Molecular Formula]
C16H14F2N4O3S | [MOL File]
2894848-07-6.mol | [Molecular Weight]
380.37 |
| Chemical Properties | Back Directory | [Boiling point ]
523.3±60.0 °C(Predicted) | [density ]
1.481±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Sparingly Soluble: 1-10 mg/ml | [form ]
Solid | [pka]
6.38±0.15(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BI 3231 is a potent and selective hydroxysteroid 17?-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases[1]. | [in vivo]
BI 3231 is rapidly cleared from plasma, considerable hepatic exposure was maintained over 48 h[1]. | [References]
[1] Thamm S, et, al. Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science. J Med Chem. 2023 Feb 2. DOI:10.1021/acs.jmedchem.2c01884 |
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