| Identification | More | [Name]
4-Ethylresorcinol | [CAS]
2896-60-8 | [Synonyms]
2,4-dihydroxy-1-ethylbenzene
2,4-DIHYDROXYETHYLBENZENE
4-ETHYL-1,3-BENZENEDIOL
4-ETHYLRESORCINOL
1,3-Dihydroxy-4-ethylbenzene
4-ethyl-3-benzenediol
6-Ethylresorcinol
Ethyl 1,3-benzenediol
Resorcinol, 4-ethyl-
4-Ethyl Resorcin
5-Ethylresorcinol
1,3-DIHYDROXY-4-ETHYLBENZENE,97+%
KO 11
5-Ethylresorcinol , (2,4-Dihydroxyl-1-ethylbenzene) | [EINECS(EC#)]
220-777-1 | [Molecular Formula]
C8H10O2 | [MDL Number]
MFCD00002283 | [Molecular Weight]
138.16 | [MOL File]
2896-60-8.mol |
| Chemical Properties | Back Directory | [Appearance]
slightly beige crystalline powder | [Melting point ]
95-98 °C (lit.) | [Boiling point ]
155 °C / 10mmHg | [density ]
1.0742 (rough estimate) | [refractive index ]
1.5231 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Solubility in methanol; almost transparency. Soluble in alcohol. | [form ]
Crystalline Powder | [pka]
10.06±0.10(Predicted) | [color ]
Slightly beige | [BRN ]
1238231 | [Cosmetics Ingredients Functions]
ANTIMICROBIAL
HAIR DYEING | [InChIKey]
VGMJYYDKPUPTID-UHFFFAOYSA-N | [LogP]
1.731 (est) | [CAS DataBase Reference]
2896-60-8(CAS DataBase Reference) | [NIST Chemistry Reference]
1,3-Benzenediol, 4-ethyl-(2896-60-8) | [EPA Substance Registry System]
2896-60-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29072100 |
| Hazard Information | Back Directory | [Description]
4-Ethylresorcinol is a derivative of resorcinol, which acts as a substrate for tyrosinase. 4-Ethylresorcinol has hypopigmentation effects.4-Ethylresorcinol attenuates the mRNA and protein expression of tyrosinase-related protein (TRP)-2, and has an antioxidant effect through the inhibition of lipid peroxidation. 4-Ethylresorcinol is a derivative of resorcinol, which acts as a substrate for tyrosinase. 4-Ethylresorcinol is a derivative of resorcinol. | [Chemical Properties]
slightly beige crystalline powder | [Uses]
It is employed as an active pharmaceutical intermediate. | [Definition]
ChEBI: 4-Ethylresorcinol is a member of resorcinols. | [Synthesis Reference(s)]
Synthetic Communications, 15, p. 1315, 1985 DOI: 10.1080/00397918508077280 | [Synthesis]
The synthesis of 4-Ethylresorcinol is as follows:
In a three necked round bottom flask (equipped with a condensor, additional funnel and mechanical stirrer) was added 15.2 g of a combination of Raney Nickel and Ni supported on silica. (50: 50). 100 ml of a mixture of 50: 50 ethanol: water was added and the reaction was heated at reflux conditions. 15.2 g of 2,4-dihydroxy acetophenone in 100 ml of water: ethanol and 10 ml of acetic acid was placed in the additional funnel and slowly added to the mixture (dropwise). The reaction was filtered through a milipore filter to give a pale yellow solution. Concentration of this solution in vacuo gave a solid. This solid was crystalized from 1,2-dichloroethane to give 4-ethyl resorcinol in 80% isolated yield.
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