| Chemical Properties | Back Directory | [Boiling point ]
599.408±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.688±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMF: 30 mg/ml
DMSO: 30 mg/ml
DMSO: PBS (pH 7.2) (1:1): 0.5 mg/ml
Ethanol: 5 mg/ml | [pka]
6.754±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
Fisetin-d5 is a deuterated labeled Fisetin[1]. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects. | [in vivo]
Fisetin treatment to UVB exposed mice results in decreased hyperplasia and reduces infiltration of inflammatory cells. Fisetin treatment also reduces inflammatory mediators such as COX-2, PGE2 as well as its receptors (EP1- EP4), and MPO activity. Furthermore, Fisetin reduces the level of inflammatory cytokines TNFα, IL-1β and IL-6 in UVB exposed skin. Fisetin treatment also reduces cell proliferation markers as well as DNA damage as evidenced by increased expression of p53 and p21 proteins[4]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Kim SC, et al. Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2015 Nov 27;467(4):638-44. DOI:10.1016/j.bbrc.2015.10.094
[3] Mukhtar E, et al. Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells. Cancer Lett. 2015 Oct 28;367(2):173-83. DOI:10.1016/j.canlet.2015.07.030 |
|
|